Yes, and it's a sensible option that plenty of people overlook. You get the Drake experience once, which is what a lot of travellers want, while halving your exposure to it and keeping some of the time saving that flying buys. If you're torn between the two, this is the middle path.
Which direction to fly is worth thinking about. Flying south and sailing home means you arrive fresh and with maximum time on site, and you take the crossing when you already have your sea legs and the mood on board is celebratory. Sailing south and flying home means you get the build-up, the briefings and the lectures on the way in, which is how the trip is designed to unfold.
It doesn't remove the flight delay risk, it halves it. And it still narrows your itinerary options compared with sailing both ways, though less severely.
Availability varies by operator and departure. Ask us which sailings offer it on the dates you're looking at.